Prediction of Acute Coronary Syndrome in Acute Ischemic Stroke (PRAISE-DZHK19 I DZNEB001)

ID

NCT03609385

Status

Closed

DZG

DZHK

Start date

08/01/2021

Contact

Contacts
  • Matthias Endres
  • Ulf Landmesser
  • Christian Nolte

Parameters

Inclusion criteria
  • diagnosis of ischemic stroke based on clinical and imaging information (CT or MRI) diagnosis of transient ischemic attack if the initial focal neurological deficit has been examined by a neurologist and if the ABCD2-score is ≥ 4 Elevation of high-sensitive cardiac troponins according to the rule-in/rule-out algorithm of the 2015 ESC guidelines for NSTE-ACS
  • i.e. highly abnormal troponin at 0 hours (> 52ng/l if hs-cTnT
  • Elecsys-Assay
  • or > 52ng/l
  • if hs-cTnI
  • Architect-Assay
  • or > 107 ng/l
  • if hs-cTnI. Dimension Vista Assay) or dynamic change > 20% of the initial value at re-test after 3 hours with at least one value above the 99th percentile of a healthy reference population ability to give informed consent onset of symptoms < 72 hours prior to hospital admission
Exclusion criteria
  • renal insufficiency (GFR < 30 ml/min/m²) contraindications for coronary angiography (e.g. manifest hyperthyroidism
  • allergy to contrast agent) lesion size > 100 ml (either on Diffusion Weighted Imaging on cMRI or on CT if CT is performed > 24 hours after onset) or ASPECTS score < 7 (on CT if CT is performed < 24 hours after onset) Premorbid degree of dependence (mRS > 3) pregnancy or breast-feeding limited life expectancy < 1 year consent to participate in the study given > 72 hours after hospital admission